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99.9% Assay Anti Estrogen Steroids CAS 120511-73-1 Anastrozole Arimidex Bodybuilding

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Good quality Anabolic Steroid Hormone for sales
Good quality Anabolic Steroid Hormone for sales
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99.9% Assay Anti Estrogen Steroids CAS 120511-73-1 Anastrozole Arimidex Bodybuilding

China 99.9% Assay Anti Estrogen Steroids CAS 120511-73-1 Anastrozole Arimidex Bodybuilding supplier
99.9% Assay Anti Estrogen Steroids CAS 120511-73-1 Anastrozole Arimidex Bodybuilding supplier 99.9% Assay Anti Estrogen Steroids CAS 120511-73-1 Anastrozole Arimidex Bodybuilding supplier 99.9% Assay Anti Estrogen Steroids CAS 120511-73-1 Anastrozole Arimidex Bodybuilding supplier

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Product Details:

Place of Origin: China
Brand Name: JIACHENG
Certification: Liquid Detection
Model Number: steroid

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Negotiable
Packaging Details: 1kg/foil bag or as required
Delivery Time: Within 8 hours after receiving the payment
Payment Terms: Western union, MoneyGram ,Bitcoin and BankWire
Supply Ability: 6000kg/month
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Detailed Product Description
Color: White Solid Powder Molecular Formula: C17H19N5
Molecular Weight: 293.37 Assay: 99.9%
Other Name: Aromasin ; Anastrozole; AriMidex; Anastrol; Anatrozole; Anastrozol; CAS: 120511-73-1

Anti Estrogen Steroids Anastrozole Arimidex / Anastrol / CAS
 
:120511-73-1 powder
 
 
 

Description:

 

Name: Anastrozole Arimidex

Alias: Aromasin ; Anastrozole; AriMidex; Anastrol; Anatrozole; Anastrozol; ICI-D-1033
ARIMIDEX; 1-[3,5-DI-(1-METHYL-1-CYANO)-ETHYL]-BENZYL-1,2,4-TRIAZOLE

CAS NO: 1120511-73-1

MF: C17H19N5

MW: 293.37

 

99.9% Assay Anti Estrogen Steroids CAS 120511-73-1 Anastrozole Arimidex Bodybuilding

 

Purity: 99.8%

 

Appearance: white solid powder.

 

Applications:

 

Anastrozole (marketed under the trade name Arimidex by AstraZeneca) is an aromatase-inhibiting drug approved for treatment of breast cancer after surgery, as well as for metastasis in both pre and post-menopausal women. The severity of breast cancer is increased by estrogen, as sex hormones cause hyperplasia, and differentiation at estrogen receptor sites. Anastrozole works by inhibiting the synthesis of estrogen. 

Medical uses

The ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial was an international randomised controlled trial of 9366 women with localized breast cancer who received either anastrozole, tamoxifen, or both for five years, followed by five years of follow-up. After more than 5 years the group that received anastrozole had significantly better clinical results than the tamoxifen group.The trial suggested that anastrozole is the preferred medical therapy for postmenopausal women with localized breast cancer that is estrogen receptor (ER) positive. Another study found that the risk of recurrence was reduced 40%, which also included an increased risk of bone fractures, and that ER negative patients benefited from switching to anastrozole.

Mechanism of action

Anastrozole binds reversibly to the aromatase enzyme through competitive inhibition, inhibits the conversion of androgens to estrogens in peripheral tissues (outside the CNS), and a few CNS sites in various regions within the brain.

Side effects

Bone weakness has been associated with anastrozole. Women who switched to anastrozole after two years on tamoxifen reported twice as many fractures as those who continued to take tamoxifen (2.1% compared to 1%). Bisphosphonates are sometimes prescribed to prevent the osteoporosis induced by aromatase inhibitors.

Usage in men

Anastrozole has been tested for reducing estrogens, including estradiol, in men. Excess estradiol in men can cause benign prostatic hyperplasia, gynecomastia, and symptoms of hypogonadism. It can also contribute to increased risk of stroke, heart attack, chronic inflammation, prostate enlargement and prostate cancer.Some athletes and body builders will also use anastrozole as a part of their steroid cycle to reduce and prevent symptoms of excess estrogens; gynecomastia and water retention. Study data suggests dosages of 0.5 mg to 1 mg a day reduce serum estradiol approx. 50% in men, which differs in postmenopausal women.

Usage in children

Anastrozole may be used off-label in children with precocious puberty, or children with pubertal gynecomastia.Following the onset of puberty, the epiphyseal plate begins to close due to an increased amount of estrogen production escaping local metabolism and spreading to the circulatory system. It is shown to help slow this process, and increase adult height prediction in adolescent males treated with protein-based peptide hormones for the treatment of growth hormone deficiency.

Chemical synthesis

Arimidex (anastrozole) 1 mg tablets

The synthesis begins with nucleophilic substitution of two benzylic bromides in α,α’-dibromomesitylene (prepared by radical bromination of mesitylene, not shown on the scheme) with cyanide by treatment with potassium cyanide under phase transfer conditions, affording the dinitrile. Exhaustive methylation with methyl iodide and sodium hydride leads to the replacement of the more acidic side chain hydrogen atoms by methyl groups. The treatment with bromine in the presence of benzoyl peroxide leads to the formation of the corresponding benzyl bromide. Reaction of that product with 1,2,4-triazole in the presence of a base completes the synthesis of the aromatase inhibitor.

 

 

COA:

 

TEST ITEMS SPECIFICATION RESULTS
Description : White Crystalline Powder White Powder
Identification : Positive Positive
Assay(by HPLC) : 98.0~102.0% 99.64%
Absorbance(E1cm) : 465~495 482.5
Melting Point : 191~195°C 193.5~195.0°C
Loss On Drying : 0.5%max 0.19%
Specific Rotation : +288°~ +298° +290.2°
Residue On Ignition : 0.1%max 0.03%
Related Substances : Total:1.5%max <1.3%
  Single:0.5%max <0.4%
Residue Solvents : 0.2%max 0.10%
Heavy Metals : 20PPm max <10PPm
Conclusion

The specification conform with enterprise standard.

 

 

 

PHOTO:

 

99.9% Assay Anti Estrogen Steroids CAS 120511-73-1 Anastrozole Arimidex Bodybuilding

 

 

OUR ADWANTAGE:

 

1, High quality with competitive price:
1) Standard: U.S Standard
2) All Purity≥99.8%
3) We are manufacturer and can provide high quality products with factory price.

 

2, Fast and safe delivery
1) Parcel can be sent out within 8 hours after payment. Tracking number available
2) Secure and discreet shipment. Various transportation methods for your choice.
3) Customs pass rate ≥99.8%
4)We provide re-ship policy.
5) We have warehouse in Australia, Canada and England, we have large amounts of stock in the warehouse, can ship to you directly from our foreign warehouse!

 

3, We have clients throughout the world.
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) Meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers..

 

 


 


 

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