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Zhuhai jiacheng Sci. & Tech. Co., Ltd

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Good quality Anabolic Steroid Hormone for sales
Good quality Anabolic Steroid Hormone for sales
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Oral Nonsteroidal Aromatase Inhibitor Femara Letrozole CAS 107868-30-4

China Oral Nonsteroidal Aromatase Inhibitor Femara Letrozole CAS 107868-30-4 supplier
Oral Nonsteroidal Aromatase Inhibitor Femara Letrozole CAS 107868-30-4 supplier Oral Nonsteroidal Aromatase Inhibitor Femara Letrozole CAS 107868-30-4 supplier Oral Nonsteroidal Aromatase Inhibitor Femara Letrozole CAS 107868-30-4 supplier

Large Image :  Oral Nonsteroidal Aromatase Inhibitor Femara Letrozole CAS 107868-30-4

Product Details:

Place of Origin: China
Brand Name: JIACHENG
Certification: Liquid Detection
Model Number: steroid

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Negotiable
Packaging Details: 1kg/foil bag or as required
Delivery Time: Within 8 hours after receiving the payment
Payment Terms: Western union, MoneyGram ,Bitcoin and BankWire
Supply Ability: 6000kg/month
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Detailed Product Description
Color: White Solid Powder Molecular Formula: C17H11N5
Molecular Weight: 285.3 Assay: 99.9%
Other Name: LETROZOL, LETROZOLE, LetrozoleUsp28,Letrozole99%, CGS-20267, Femara, LETRAZOLE, Letrozolex, Lelrozol, Letroz CAS: 112809-51-5

Oral non-steroidal aromatase inhibitor Femara (Letrozole) / CAS
 
107868-30-4 powder

 

Description:

 

Letrozole

 

Alias: 4,4'-(1H-1,2,4-TRIAZOL-1-YLMETHYLENE) BIS-BENZONITRILE,FEMARA,CGS-20267, LETROZOL, LETROZOLE, LetrozoleUsp28,Letrozole99%, CGS-20267, Femara, LETRAZOLE, letrozolex, Lelrozol, Letroz

 

CAS NO: 112809-51-5

MF: C17H11N5

MW: 285.3

Oral Nonsteroidal Aromatase Inhibitor Femara Letrozole CAS 107868-30-4

Purity: 99.8%

Appearance: white solid powder.

 

 

Applications:

 

Letrozole (INN, trade name Femara) is an oral non-steroidal aromatase inhibitor for the treatment of hormonally-responsive breast cancer after surgery.

Estrogens are produced by the conversion of androgens through the activity of the aromatase enzyme. Estrogens then bind to an estrogen receptor, which causes cells to divide.

Letrozole prevents the aromatase from producing estrogens by competitive, reversible binding to the heme of its cytochrome P450 unit. The action is specific, and letrozole does not reduce production of mineralo- or corticosteroids.

Uses

Femara 2.5mg oral tablet

Letrozole is approved by the United States Food and Drug Administration (FDA) for the treatment of local or metastatic breast cancer that is hormone receptor positive or has an unknown receptor status in postmenopausal women. Side effects include signs and symptoms of hypoestrogenism. There is concern that long term use may lead to osteoporosis, which is why prescriptions of Letrozole are often accompanied by prescriptions of osteoporosis-fighting medications such as bisphosphonates.

Off-label use

Letrozole has been used for ovarian stimulation by fertility doctors since 2001—having fewer side-effects than clomifene (Clomid) and less chance of multiple gestation. A Canadian study presented at the American Society of Reproductive Medicine 2005 Conference suggests that Letrozole may increase the risk of birth defects. A more detailed ovulation induction follow-up study found that letrozole, compared with a control group of clomiphene, had significantly lower congenital malformations and chromosomal abnormalities at an overall rate of 2.4% (1.2% major malformations) compared with clomiphene 4.8% (3.0% major malformations). Despite this, India banned the usage of Letrozole in 2011, citing potential risks to infants.

The anti-estrogen action of letrozole has been shown to be useful in pretreatment for termination of pregnancy, in combination with misoprostol. It can be used in place of mifepristone, which is expensive and unavailable in many countries.

The anti-estrogen action of Letrozole is preferred by athletes and bodybuilders for use during a steroid cycle to reduce bloating due to excess water retention and prevent the formation of gynecomastia related breast tissue that is a side effect of some anabolic steroids.

Some studies have shown that Letrozole can be used to promote spermatogenesis in male patients suffering from nonobstructive azoospermia.

Letrozole has also been shown to delay the fusing of the growth plates in mice. When used with growth hormone, Letrozole has been shown therapeutic for adolescents and children with short stature.

Letrozole has also been used to treat endometriosis.

Comparison with tamoxifen

Tamoxifen is also used to treat hormonally-responsive breast cancer, but it does so by interfering with the estrogen receptor. However, letrozole is effective only in post-menopausal women, in whom estrogen is produced predominantly in peripheral tissues (i.e. in adipose tissue, like that of the breast) and a number of sites in the brain. In pre-menopausal women, the main source of estrogen is from the ovaries not the peripheral tissues, and letrozole is ineffective.

In the BIG 1-98 Study, of post-menopausal women with hormonally-responsive breast cancer, letrozole reduced the recurrence of cancer, but did not change survival rate, compared to tamoxifen.

Contraindications

Letrozole is contraindicated in women having a pre-menopausal hormonal status, during pregnancy and lactation.

Adverse effects

The most common side effects are sweating, hot flashes, arthralgia (joint pain), and fatigue.

Interactions

Letrozole inhibits the liver enzyme CYP2A6, and to a lesser extent CYP2C19, in vitro, but no relevant interactions with drugs like cimetidine and warfarin have been observed.

 

 

COA:

 

TEST ITEMS SPECIFICATION RESULTS
Description : White Crystalline Powder White Powder
Identification : Positive Positive
Assay(by HPLC) : 98.0~102.0% 99.64%
Absorbance(E1cm) : 465~495 482.5
Melting Point : 191~195°C 193.5~195.0°C
Loss On Drying : 0.5%max 0.19%
Specific Rotation : +288°~ +298° +290.2°
Residue On Ignition : 0.1%max 0.03%
Related Substances : Total:1.5%max <1.3%
  Single:0.5%max <0.4%
Residue Solvents : 0.2%max 0.10%
Heavy Metals : 20PPm max <10PPm
Conclusion

The specification conform with enterprise standard.

 

 

 

PHOTO:

 

Oral Nonsteroidal Aromatase Inhibitor Femara Letrozole CAS 107868-30-4

 

We have good prices, high quanlity,best package methods, safety shippment, more

 

important,we provide re-ship policy, so there are not any loss once you order from us

 

and I guarantee delivery and your interests!

 

 

OUR ADWANTAGE:

 

1, High quality with competitive price:
1) Standard: U.S Standard
2) All Purity≥99.8%
3) We are manufacturer and can provide high quality products with factory price.

 

2, Fast and safe delivery
1) Parcel can be sent out within 8 hours after payment. Tracking number available
2) Secure and discreet shipment. Various transportation methods for your choice.
3) Customs pass rate ≥99.8%
4)We provide re-ship policy.
5) We have warehouse in Australia, Canada and England, we have large amounts of stock in the warehouse, can ship to you directly from our foreign warehouse!

 

3, We have clients throughout the world.
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) Meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers..

 

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